SS-31

Product Introduction：

SS-31 (also known as Elamipretide, MTP-131, Bendavia) is a synthetic, mitochondria-targeted tetrapeptide with exceptional stability and water solubility. This uniquely structured peptide selectively accumulates in the inner mitochondrial membrane, where it binds to cardiolipin to stabilize mitochondrial structure and function. Extensively researched for its powerful antioxidant and cellular protective properties, SS-31 has shown great potential in reducing oxidative stress, enhancing ATP production, and supporting overall cellular energy metabolism.
It has demonstrated promising effects in promoting mitochondrial biogenesis, protecting against ischemia-reperfusion injury, and supporting cardiovascular health. SS-31 also exhibits notable neuroprotective properties, with research indicating its ability to improve cognitive function, reduce neuronal damage, and support brain health. Additionally, it may help enhance exercise performance, accelerate muscle recovery, and alleviate age-related mitochondrial dysfunction. Studies have explored its potential applications in supporting conditions linked to oxidative stress and mitochondrial impairment, including heart failure, neurodegenerative diseases, and age-related muscle decline. Requires reconstitution before use.

• How does SS-31 work?

SS-31 exerts its effects through highly targeted mitochondrial mechanisms:
Mitochondrial Targeting & Cardiolipin Stabilization: SS-31 is a cell-permeable tetrapeptide that selectively accumulates in the inner mitochondrial membrane, where it binds to cardiolipin, a critical mitochondrial phospholipid. This binding stabilizes mitochondrial structure, preserves membrane integrity, and maintains optimal mitochondrial function.
Antioxidant & Oxidative Stress Reduction: By protecting mitochondrial structure, SS-31 directly reduces reactive oxygen species (ROS) production, mitigates oxidative damage to cellular components, and enhances the cell’s natural antioxidant defense systems.
Energy Metabolism Enhancement: SS-31 improves mitochondrial respiratory chain function, boosts ATP production, and supports efficient cellular energy metabolism, which is essential for all tissue and organ function.

• Research

Neuroprotective Effects: Extensive preclinical research demonstrates SS-31’s ability to cross the blood-brain barrier, protect neurons from oxidative stress and ischemia-reperfusion injury, reduce neuronal apoptosis, and support cognitive function in models of neurodegenerative diseases.
Cardiovascular Protection: Studies show SS-31 reduces myocardial ischemia-reperfusion injury, improves cardiac function in heart failure models, enhances endothelial function, and supports overall cardiovascular health by protecting mitochondrial function in cardiac cells.
Anti-Aging & Metabolic Support: Research indicates SS-31 alleviates age-related mitochondrial dysfunction, improves muscle function and strength in aging models, and supports metabolic health by enhancing cellular energy utilization.
Tissue Repair & Recovery: SS-31 has shown potential in promoting tissue recovery after injury, reducing inflammation, and accelerating healing in multiple tissue types by protecting cellular energy production.

• Side Effects

The most common side effects associated with SS-31 include:
– Mild injection site reactions (redness, swelling, itching)
– Transient headache
– Mild gastrointestinal discomfort (nausea, bloating)
– Fatigue (rare, typically mild and temporary)

• Summary

SS-31 (Elamipretide) represents a groundbreaking advancement in mitochondrial-targeted peptide research, offering a potent tool for investigating the critical role of mitochondrial function in cellular health, aging, and disease. Its demonstrated efficacy in neuroprotection, cardiovascular support, oxidative stress reduction, and anti-aging effects makes it a valuable subject for ongoing research into neurodegenerative disorders, cardiovascular diseases, and age-related functional decline. As research into mitochondrial biology continues to expand, SS-31 may provide key insights into novel therapeutic strategies for addressing a wide range of conditions linked to mitochondrial dysfunction.

• Resource

All products on this site are for research and development use only. Products are not for human consumption of any kind. The statements made on this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure, or prevent any disease. Power Peptides is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Power Peptides is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act. All products are sold for research, laboratory, or analytical purposes only, and are not for human consumption. Power Peptides Products are intended strictly for research purposes only. These products are not approved by the US Food and Drug Administration (FDA) for human consumption or medical use. Under no circumstances should these peptides be used for any purpose other than research. By purchasing or using our peptides, you acknowledge and agree that you will use them solely in accordance with applicable laws and regulations and that you accept full responsibility for their use. Statements made on this website have not been evaluated by the USA Food and Drug Administration.